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By Quinlan A., Last update 1494698999
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pairToPair description

pairToPair compares two BEDPE files in search of overlaps where each end of a BEDPE feature in A overlaps with the ends of a feature in B. For example, using pairToPair, one could screen for the exact same discordant paired-end alignment in two files. This could suggest (among other things) that the discordant pair suggests the same structural variation in each file or sample.

Parent program: BEDTools

bedtools utilities are a swiss-army knife of tools for a wide-range of genomics analysis tasks. The most widely-used tools enable genome arithmetic: that is, set theory on the genome. For example, bedtools allows one to intersect, merge, count, complement, and shuffle genomic intervals from multiple files in widely-used genomic file formats such as BAM, BED, GFF, GTF, VCF. While each individual tool is designed to do a relatively simple task (e.g., intersect two interval files), quite sophisticated analyses can be conducted by combining multiple bedtools operations on the UNIX command line.